ea0021oc1.5 | Diabetes and metabolism | SFEBES2009
Buss Nicholas
, Gavins Felicity
, Gresham Stephanie
, Cover Patricia
, Terron Andrea
, Buckingham Julia
The anti-inflammatory protein, annexin 1 (ANXA1) acts via a formyl peptide receptor (FPR), possibly FPR2, in the neuroendocrine system to mediate feedback effects of glucocorticoids and thereby modulate the HPA responses to immune insults. Here, we explored further the role of ANXA1 and the FPR family in mediating the HPA responses to endotoxin (LPS), focusing on the adrenal cortex.Adult male mice treated with LPS (500 μg/kg, i.p.) showed time-depen...